PATENTS
October 30, 2018
Abstract: Disclosed here is a method of detecting traumatic brain injury in a subject, comprising collecting a biological sample from the subject; analyzing the biological sample to determine the level of at least one protein selected from ALDOA, PHKB, HBA-A1, DPYSL2, SYN1 and/or CKB; and determining whether the level of the at least one protein exceeds a predetermined threshold.
In certain aspects, the method further comprises the step of administering a treatment to the subject if the at least one protein exceeds the predetermined threshold. The disclosed technology relates generally to brain injuries, and in particular to a panel of serum based biomarkers that can identify individuals with mild traumatic brain injury (TBI).
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U.S. Patent Application No. 17/591,521; Filing Date: February 2, 2022
Matthew Harper, Michael Anderson, Kacie Meyer, Laura M. Dutca, Manohar John, Randy Kardon, Inventors.
October 30, 2018
Abstract: Disclosed are methods for identifying one or more amino acid molecules and nucleic acid molecules encoding such amino acid molecules of at least two proteomes that are conserved, unique or express at higher or lower levels in at least one of the proteomes.
Expression libraries are used that produce the proteome, and in one embodiment, may produce the proteome from at least one cDNA expression library in one to five reactions. Anti-proteome antibodies are prepared that selectively bind to one of the proteomes and binding with at least one second proteome compared.​
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Patent number: 10114025
February 13, 2019
Abstract:
Provided are aggregate alpha-synuclein specific antibodies as well as fragments, derivatives, and variants thereof as well as method related thereto for the early diagnostic and treatment of Parkinson's Disease and other Lewy body- and Lewy neurite-based diseases. Assays, kits, systems, and nanoparticle encapsulated compositions related to the antibodies or fragments, derivatives, and variants thereof are also disclosed.
US Patent Application Number: 62804805
